8月4日，由中國科學技術交流中心、北京天壇醫院國家神經系統疾病臨床醫學研究中心、中國老年學和老年醫學學會共同主辦的運動障礙性疾病尚未滿足的臨床需求與對策 — 2024“中美健康橋”暨第六屆天壇人腦組織庫研討會在北京天壇醫院國家神經系統疾病臨床醫學研究中心（以下簡稱：國家中心）成功舉辦。本次活動由國家中心腦庫、美國UC Davis神經內科、北大神經病學系和北京五洲融合創新產業戰略研究院聯合舉辦，并受到國際帕金森病與運動障礙性疾病學會（MDS）的支持。本次研討會邀請了中外高級別專家39位共話運動障礙性疾病領域，吸引線下約100余人參會，線上觀眾近2.9萬余人次。

       活動于上午8點正式開始，由北京五洲融合創新產業戰略研究院理事長張璋主持，北京天壇醫院黨委副書記賈旺，中國紅十字會會長、中國科學院院士陳竺，國際帕金森病與運動障礙性疾病學會主席Victor S.C. Fung，中國科學技術交流中心主任高翔出席致辭。

      賈旺熱情歡迎參會嘉賓，他說道“醫學家有國籍，但醫學沒有國界”，運動障礙性疾病需要多學科協作，期待中美專家共同探討精準診療新路徑，為患者提供最佳治療模式。

      陳竺在視頻致辭中祝賀會議召開，他提出加強基礎研究、推動技術創新和國際合作，以應對疾病挑戰，并鼓勵加強人腦組織庫建設，促進資源共享，提升診療水平。

      Victor S.C. Fung介紹國際帕金森病與運動障礙性疾病學會的全球影響力和會員構成，強調運動障礙性疾病診治的緊迫性，呼吁專家共同促進知識傳播、診斷和治療。

      高翔回顧中美科技合作歷史，強調健康領域合作的重要性，期待未來繼續通過“中美健康橋”系列活動，推動兩國科學家之間的交流合作，造福人類健康。

      研討會期間，與會專家們圍繞“識別運動障礙性疾病未滿足的臨床需求”“非典型帕金森病”“運動障礙性疾病臨床未滿足需求的解決方案”“人腦組織庫建設”等方向，為大家帶來了前沿的研究成果和獨到的見解。

      針對“識別運動障礙性疾病未滿足的臨床需求”，國家老年醫學臨床醫學研究中心的陳彪教授聚焦臨床前期帕金森病的識別；加州大學圣地亞哥分校的Irene Litvan教授強調早期發現罕見神經系統疾病的必要性；北京天壇醫院的黃越教授詳細介紹團隊亨廷頓病隊列的臨床研究，為與會者提供臨床研究的啟發。同時，澳大利亞新南威爾士大學醫學系的Margaret Morris教授分享腸腦途徑對運動障礙性疾病影響的新成果；美國加州大學戴維斯分校的劉茵教授和澳大利亞新南威爾士大學醫學院健康衰老研究中心的Perminder Sachdev教授分別解碼帕金森病及其他運動障礙的視覺表現和藥物引起的相關問題。

      下午的兩個分會場也精彩不斷。分會場1邀請到來自美國加州大學戴維斯分校、北京大學第一醫院、北京天壇醫院、澳大利亞墨爾本大學以及北京中醫藥大學東方醫院的專家學者參與探討兩大問題。

      首先在“非典型帕金森病”的分享中，美國加州大學戴維斯分校的Masud Seyal教授、Orwa Aboud教授和Marc Lenaerts教授圍繞帕金森病、癲癇、腦腫瘤及頭痛挑戰等議題分享了最新的研究成果和治療方法。

      接著在“運動障礙性疾病臨床未滿足需求的解決方案”的討論中，馮濤教授、鄧健文研究員、王鐸醫生針對運動障礙性疾病的生物標志物與臨床評估，探討未來的臨床需求和發展方向;張琳教授、Anthony Hannan教授、張建國教授、陳志剛教授團隊的趙千玉醫生分別從臨床經驗、發病機制、DBS治療和中醫藥運用等角度，探尋運動障礙性疾病的治療方案，期待惠及更多患者。

      在分會場2，第六屆天壇人腦組織庫研討會上，中國人體器官捐獻管理中心副主任張宗偉介紹了我國人體組織捐獻的現狀；國家科技基礎條件平臺中心處長盧凡就腦庫支撐的科研范式變革提出了深入思考；加拿大不列顛哥倫比亞大學研究員Tanya Barretto從倫理學的角度探討了人類研究的邊界與責任；北京天壇醫院的黃越教授團隊的醫生關惠盈對天壇醫院國家人腦組織庫的相關情況進行了匯報。

      研討會還特別設置臨床病例病理討論環節，通過真實案例的分享與討論，加深參會者對運動障礙性疾病臨床特征、病理機制及診療策略的理解。由北京天壇醫院黃越教授團隊成員匯報病例病理，參與討論的有首醫宣武醫院的馬敬紅教授、北京友誼醫院的脫厚珍教授、北大醫院的王朝霞教授、山東齊魯醫院的劉藝鳴教授，北京天壇醫院的王群教授、以及來自美國UC Davis的張琳教授和Masud Sayel教授，以及北京邁基諾基因科技股份有限公司的遺傳咨詢師史明琪，和來自安徽等外地醫院的醫生也來到現場參加了討論。臨床醫生圍繞著帕金森病患者、喪失行走能力患者及不自主運動患兒等案例，展開了深入的分析與討論，為臨床實踐提供了寶貴的經驗和啟示。

      本次研討會為國內外運動障礙性疾病的研究者們搭建了交流與合作的平臺，推動了該領域研究的深入發展，是“中美健康橋”推進民間科技交流的又一重要篇章。期待全球專家學者能夠為運動障礙性疾病的研究和診療提出新方案，為人類社會早日攻克腦疾病探索新路徑！

Tackle the Unmet Clinical Needs for Movement Disorders: The 2024 "Sino-US Health Bridge" and the 6th Tiantan Human Brain Tissue Banking Symposium were successfully held!

On August 4, the 2024 "Sino-US Health Bridge" and the 6th Tiantan Human Brain Tissue Banking Symposium on “Tackle the Unmet Clinical Needs for Movement Disorders”, co-organized by the China Science and Technology Exchange Center, the National Clinical Research Center for Neurological Diseases (NCRCND) of Beijing Tiantan Hospital, Capital Medical University, and the Chinese Society of Gerontology and Geriatrics was successfully held at NCRCND, Beijing Tiantan Hospital. The event was jointly organized by the Human Brain Bank - NCRCND, the Department of Neurology at UC Davis in United States, the Departments of Neurology at Peking University and the Beijing Wuzhou Institute of Integrated Innovation Industry Strategy, and endorsed by the International Society for Parkinson's and Movement Disorders (MDS). The symposium invited 39 experts from China and abroad to discuss topics in the field of movement disorders, attracting more than 100 participants in person and nearly 29,000 audiences online.

The event officially started at 8 a.m., presided over by Zhang Zhang, Chairman of Beijing Wuzhou Institute of Integrated Innovation Industry Strategy, Jia Wang, Deputy Secretary of the Party Committee of Beijing Tiantan Hospital, Chen Zhu, President of the Red Cross Society of China and Academician of the Chinese Academy of Sciences, Victor S.C. Fung, President of the International Society of Parkinson's Disease and Movement Disorders, and Gao Xiang, Director of the China Science and Technology Exchange Center, gave the opening speeches.

Deputy Secretary Wang Jia warmly welcomed the guests. He said, "Medical scientists have nationality, but medicine has no borders". Movement disorders require multidisciplinary collaboration, and he looks forward to Chinese and American experts to discuss new ways of precision diagnosis and treatment to provide patients with the best treatment.

Academician Zhu Chen congratulated the convening of the conference in a video speech, and proposed to strengthen basic research, promote technological innovation and international cooperation to meet the challenges of diseases, and encourage to strengthen the human brain tissue banking, promote resource sharing, and improve the accuracy of the diagnosis and accessibility of treatments. 

President Victor S.C. Fung introduced the global influence and membership of the International Society of Parkinson's Disease and Movement Disorders, emphasized the urgency of the diagnosis and treatment of movement disorders, and called on experts to jointly promote knowledge dissemination.

Mr. Xiang Gao reviewed the history of China-US cooperation in science and technology, emphasized the importance of cooperation in the field of health, and looked forward to continuing to promote exchanges and cooperation between scientists of the two countries through the "China-US Health Bridge" series of activities in the future to benefit human health.

During the seminar, the participating experts brought cutting-edge research results and unique insights in the four themes of "identifying unmet clinical needs of movement disorders", "atypical Parkinson's disease", "solutions to the unmet clinical needs of movement disorders", and " human brain tissue banking".

In response to the "identification of unmet clinical needs for movement disorders", Professor Biao Chen from the National Clinical Research Center for Geriatrics focused on the identification of preclinical Parkinson's disease; Professor Irene Litvan of the University of California, San Diego, emphasized the need for early detection of rare neurological diseases; Professor Yue Huang from Beijing Tiantan Hospital, Capital Medical University, introduced the clinical studies of Huntington's disease, and provided inspiration for clinical research. At the same time, Professor Margaret Morris from the faculty of Medicine & Health, the University of New South Wales in Australia shared new results on the impact of the gut-brain pathway on movement disorders; Professor Yin Liu from the University of California, Davis in United States and Professor Perminder Sachdev from the Centre for Healthy Aging Research at the Faculty of Medicine of the University of New South Wales in Australia decoded the visual manifestations of Parkinson's disease and other movement disorders and drug-induced problems, respectively.

There were two sessions in the afternoon, which were also exciting. Session 1 invited experts and scholars from the University of California, Davis in United States, Peking University First Hospital, Beijing Tiantan Hospital affiliated to Capital Medical University, University of Melbourne in Australia and Eastern Hospital of Beijing University of Chinese Medicine to discuss two major issues.

First of all, in the sharing of "Atypical Parkinson's Disease", Professor Masud Seyal, Professor Orwa Aboud and Professor Marc Lenaerts from the University of California, Davis, United States, shared the latest research results and treatments around Parkinson's disease, epilepsy, brain tumors and headache challenges.

Then, in the discussion of "Solutions to the Unmet Clinical Needs of Movement Disorders", Professor Tao Feng, Dr. Jianwen Deng, and Dr. Duo Wang discussed the future clinical needs and development directions for biomarkers and clinical evaluation of movement disorders. Prof. Lin Zhang, Prof. Anthony Hannan, Prof. Jianguo Zhang, and Dr. Qianyu Zhao from the team of Prof. Zhigang Chen explored the treatment options for movement disorders from the perspectives of clinical experience, pathogenesis, DBS treatment and application of traditional Chinese medicine, and looked forward to benefiting more patients.

In session 2, the 6th Tiantan Human Brain Tissue Banking Seminar was taken place. Mr. Zongwei Zhang, deputy director of the Chinese Human Organ Donation Management Center, introduced the current situation of human tissue donation in China; Mr. Fan Lu from the National Science and Technology Infrastructure Platform Center put forward in-depth thoughts on the transformation of scientific research paradigms supported by brain banks; Ms. Tanya Barretto from the University of British Colombia, Canada, discussed the boundaries and responsibilities of human research from an ethical perspective; Dr. Huiying Guan from Professor Yue Huang’s group of Beijing Tiantan Hospital affiliated to Capital Medical University reported on the relevant situation of the National Human Brain Tissue Bank of Tiantan Hospital.

The session also set up a clinical pathological conference (CPC), through sharing and discussion of cases, to deepen the participants' understanding of the clinical characteristics, pathological features and diagnosis and treatment strategies of movement disorders. Professor Huang Yue's team from Beijing Tiantan Hospital reported on the neuropathology of the case, and the discussion was attended by Professor Jing-Hong Ma from Xuanwu Hospital, Professor Hou-Zhen Duo from Beijing Friendship Hospital, Professor Zhao-Xia Wang from Peking University Hospital, Professor Yi-Ming Liu from Shandong Qilu Hospital, Professor Qun Wang from Beijing Tiantan Hospital, Professor Lin Zhang and Professor Masud Sayel from UC Davis in United States, and genetic counselor Ming-Qi Shi from Beijing Mygenetics Technology Co., Ltd. and doctors from hospitals in Anhui and other places also came to the scene to participate in the discussion. Clinicians have conducted in-depth analysis and discussion on the cases of patients with Parkinson's disease, patients with inability to walk and children with involuntary movements, providing valuable experience and enlightenment for clinical practice.

This symposium has built a platform for exchanges and cooperation among researchers on movement disorders at home and abroad, promoted the in-depth development of research in this field, and is another important chapter in the "Sino-US Health Bridge" to promote non-governmental scientific and technological exchanges. It is expected that experts and scholars around the world can put forward new solutions for the research, diagnosis and treatment of movement disorders, and explore new paths for human society to overcome brain diseases as soon as possible!