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王永剛 主任醫(yī)師，教授，博生導(dǎo)師，頭痛科主任

2007年 博士畢業(yè) 于 第二軍醫(yī)大學(xué)

2007年-2013年 上海市第十人民醫(yī)院 神經(jīng)內(nèi)科  住院/主治/副主任醫(yī)師 副教授 碩士生導(dǎo)師

2013年-2019年 上海交通大學(xué)醫(yī)學(xué)院附屬仁濟(jì)醫(yī)院  神經(jīng)內(nèi)科   副主任醫(yī)師 副教授 碩士生導(dǎo)師/ 主任醫(yī)師 教授 博士生導(dǎo)師

2019年-至今      首都醫(yī)科大學(xué)附屬北京天壇醫(yī)院 神經(jīng)病學(xué)中心 頭痛科 科主任   主任醫(yī)師/教授 /博士生導(dǎo)師

擅長各種原發(fā)性頭痛（偏頭痛，緊張型頭痛，叢集性頭痛）、復(fù)雜頭痛（藥物過度使用頭痛，新發(fā)每日持續(xù)性頭痛）、青少年頭痛以及繼發(fā)性頭痛的診斷與治療；以及頭痛及其他神經(jīng)系統(tǒng)疾病合并的頭暈，情緒和睡眠障礙等疾病的藥物綜合治療。

研究方向： 1. 原發(fā)性頭痛的診療與臨床研究  2. 原發(fā)性頭痛的神經(jīng)生物學(xué)機制探討  3. 神經(jīng)損傷與修復(fù)的機制研究  4. 頭痛相關(guān)的睡眠障礙，情感障礙等共患病的臨床診療。

發(fā)表論文：

1. Fine-mapping of ZDHHC2 identifies risk variants for schizophrenia in the Han Chinese population. Zhang, H., Li, X., Ma, C., Wang, K., Zhou, J., Chen, J., Wang, Y., & Shi, Y. Mol Genet Genomic Med. 2020 Mar 17:e1190.  IF=1.995

2. Lower Vitamin D Levels in Panic attacks in Shanghai: A Case-Control Study. Asian Journal of Psychiatry. Liu C, Jiang W, Deng M, Wang F, Wang Y. Asian J Psychiatr. 2020 Feb 18 51:101948.  IF=2.529

3. SLC39A8 is a risk factor for schizophrenia in Uygur Chinese: a case-control study. Jian X, Chen J, Li Z, Song Z, Zhou J, Xu W, Liu Y, Shen J, Wang Y, Yi Q, Shi Y. BMC Psychiatry. 2019 Sep 18;19(1):293. IF=2.666

4. Predictors of relapse in patients with medication overuse headache in Shanghai: A retrospective study with a 6-month follow-up. Xin Yuan, Weiqing Jiang, Xiao Ren, Chen Liu, Yuanmei Pan, Jing Zou, Xianguo Jiang, Weihua Ji, Ying Li, Zhiying Feng, Lingling Yao, Yonggang Wang, J Clin Neurosci. 2019 Dec;70:33-36. IF=1.593

5. Association of fat mass and obesity-associated and retinitis pigmentosa guanosine triphosphatase (GTPase) regulator-interacting protein-1 like polymorphisms with body mass index in Chinese women. Chen B, Li Z, Chen J, Ji J, Shen J, Xu Y, Zhao Y, Liu D, Shen Y, Zhang W, Shen J, Wang Y, Shi Y. Endocr J. 2018 Jul 28;65(7):783-791. IF=1.911

6. Association study of NDST3 gene for schizophrenia, bipolar disorder, major depressive disorder in the Han Chinese population. Wang L, Chen J,  Li, Z, Sun W, Chen B, Li S, Li W, Lu D, Wang Y, Shi Y. AM J MED GENET B, 2018 Jan;177(1):3-9. IF=3.016

7. SNAP25 is associated with schizophrenia and major depressive disorder in the Han Chinese population. Wang Q, Wang Y, Ji W, Zhou G, He K, Li Z, Chen J, Li W, Wen Z, Shen J, Qiang Y, Ji J, Wang Y, Shi Y, Yi Q, Wang Y. J Clin Psychiatry. 2015 Jan;76(1):e76-82. doi: 10.4088/JCP.13m08962. IF=5.498

8. The GluN2B subunit of N-methy-D-asparate receptor regulates the radial migration of cortical neurons in vivo. Jiang H, Jiang W, Zou J, Wang B, Yu M, Pan Y, Lin Y, Mao Y, Wang Y. Brain Res. 2015 Jun 12;1610(3):20-32. IF=2.561

9. Common Variants in the CDH7 Gene are Associated with Major Depressive Disorder in the Han Chinese Population. Xingwang Li, Qingzhong Wang, Kuanjun He, Zhiqiang Li, Jianhua Chen, Wenjin Li, Zujia Wen, Jiawei Shen, Yu Qiang, Jue Ji, Guoyin Feng, Guang He, He Lin, Yonggang Wang, Yongyong Shi.　Behav Genet 2014 44(2):97–101 IF=2.839

10. L-3-n-butylphthalide protects rats’ cardiomyocytes from ischaemia/reperfusion-induced apoptosis by affecting the mitochondrial apoptosis pathway. Yonggang Wang, Yi Li,  C.-Y. Wang,  J.-W. Ai,  X.-Y. Dong,  H.-Y. Huang,  Z.-Y. Feng, Y.-M. Pan,  Y. Lin,  B.-X. Wang  and L.-L. Yao. Acta Physiologica 2014 Mar;210(3):524-33 IF=2.496

11. Expression and ultrastructural localization of Mint2 in the spinal cord of rats. Yao LL, Liu XY, Jin JY, Tao BB, Chen YJ, Yu YC, Bian WH, Yu J, Huang J, Wang YG. Molecular Biology Reports 2011 ;38(1):667-73 IF=2.929

12. Hydrogen sulfide protects cardiomyocytes from hypoxia/ reoxygenationinduced apoptosis by preventing GSK-3β-dependent opening of mPTP. Yao LL, Huang XW, Wang YG, Cao YX, Zhang CC, Zhu YC. Am J Physiol Heart Circ Physiol. 2010 May;298(5):H1310-9 IF=3.881

13. Survivin is involved in the anti-apoptotic effect of edaravone in PC12 cells. Xue-Yuan Liu, Ling-Ling Yao, Yu-Juan Chen, Bei-Bei Tao, Yong-Chun Yu, Wei-Hong Bian, Jing Yu and Yong-Gang Wang. Mol Cell Biochem. 2009 Jul;327(1-2):21-8. IF=1.896

14. Interaction of mint2 with TRKA is involved in regulation of nerve growth factor-induced neurite outgrowth. Yong Zhang,? , Yong-Gang Wang?, Qi Zhang, Xiu-Jie Liu, Xuan Liu, Li Jiao, Wei Zhu, Zhao-Huan Zhang, Xiao-Lin Zhao and Cheng He. J.Biol.Chem.2009 May 1;284(18):12469-79. IF=1.896

15. Nogo-A inhibits necdin-accelerated neurite outgrowth by retaining necdin in the cytoplasm. Xiujie Liu?, Yonggang Wang?, Yong Zhang, Wei Zhu, Xiaohui Xu, Michio Niinobe, Kazuaki Yoshikawa, Changlin Lu, Cheng He. Molecular and Cellular Neuroscience  2009 May;41(1):51-61. IF=3.596

16. Ling-Ling Yao,*, Yong-Gang Wang,*, Wen-Jie Cai, Tai Yao and Yi-Chun Zhu, Survivin mediates the anti-apoptotic effect of δ-opioid receptor stimulation in cardiomyocytes. Journal of Cell Science 2007, 120(5), 895-907. IF=6.383

17. Ling-Ling Yao1,*, Yong-Gang Wang2, Xiu-Jie Liu3, Yu Zhou1, Na Li1, Jun Liu1, Yi-Chun Zhu1 Phenylephrine protects cardiomyocytes from starvation-induced apoptosis by increasing glyceraldehyde-3-phosphate dehydrogenase (GAPDH) activity Journal of Cellular Physiology  published online: 21 JUN 2012 DOI: 10.1002/jcp.24053. IF=4.218

18. Yong Zhang*, Wei Zhu*, Yong-Gang Wang, Xiu-Jie Liu, Li Jiao, Xuan Liu, Zhao-Huan Zhang, Chang-Lin Lu and Cheng He? Interaction of SH2-Bβ with RET is involved insignaling of GDNF-induced neurite outgrowth. Journal of Cell Science 2006, 119(8), 1666-1676 IF=6.427

國家自然科學(xué)基金項目：

1. 項目編號：91849104，國家自然科學(xué)基金委重大研究計劃培育項目，《RBM8a介導(dǎo)Wnt信號調(diào)節(jié)神經(jīng)元再生在衰老過程中的作用及機制研究》50萬元 2019.01 - 2021.12

2. 項目編號：31770800，國家自然科學(xué)基金委面上項目資助，《內(nèi)源性硫化氫影響斑馬魚腦血管發(fā)育的機制研究》55萬元 2018.01-2021.12

3. 項目編號：20161414，上海市教委——高峰臨床醫(yī)學(xué)“研究型醫(yī)師”,《重癥肌無力及相關(guān)神經(jīng)免疫疾病抗體檢測技術(shù)臨床應(yīng)用與推廣》100萬元，2016.07-2019.06

4. 項目編號：81571329，國家自然科學(xué)基金委面上項目資助，《漢族人群重癥抑郁癥候選基因篩查、分子網(wǎng)絡(luò)分析及其功能驗證》68.4萬元  2016.01-2019.12

5. 項目編號：31240001，國家自然科學(xué)基金委專項基金資助， 《Trpc3/6介導(dǎo)Neuregulin-1引起的鈣內(nèi)流參與外周雪旺細(xì)胞髓鞘化》 15萬元， 2012.06—2013.05；

6. 項目編號：31271140，國家自然科學(xué)基金委面上項目資助，《神經(jīng)干細(xì)胞巢內(nèi)小膠質(zhì)細(xì)胞對Wnt/β-catenin通路的調(diào)節(jié)機制及其在多發(fā)性硬化發(fā)病中的機制研究》 80萬元， 2013.01—2016.12；